Abcam, ab287070, CCT-251921

Size: 1mg / 5mg
MW 410.9 Da, Purity >98%. CCT-251921 is a potent, selective, small-molecule modulator of the mediator complex-associated kinases CDK8 and CDK19 (IC₅₀, CDK8 = 2.3 nM; CDK19 = 2.6 nM).
Key facts
CAS number:1607837-31-9,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:410.9 Da,
Molecular formula:C21H23ClN6O,
PubChem:74222277,
Nature:Synthetic,
Solubility:>25 mg/ml in DMSO,
Biochemical name:8-[2-Azanyl-3-Chloranyl-5-(1-Methylindazol-5-Yl)pyridin-4-Yl]-2,8-Diazaspiro[4.5]decan-1-One,
Biological description:CCT-251921 is a potent, selective, small-molecule modulator of the mediator complex-associated kinases CDK8 and CDK19 (IC₅₀, CDK8 = 2.3 nM; CDK19 = 2.6 nM).,
Canonical smiles:CN1C2=C(C=C(C=C2)C3=CN=C(C(=C3N4CCC5(CCNC5=O)CC4)Cl)N)C=N1,
InChi:InChI=1S/C21H23ClN6O/c1-27-16-3-2-13(10-14(16)11-26-27)15-12-25-19(23)17(22)18(15)28-8-5-21(6-9-28)4-7-24-20(21)29/h2-3,10-12H,4-9H2,1H3,(H2,23,25)(H,24,29),
InChiKey:VPJXPDLMACOGIZ-UHFFFAOYSA-N,
IUPAC Name:8-[2-amino-3-chloro-5-(1-methylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B2502 CCT-251921. B2502-1 is the same size as the 1 mg size of ab287070.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cdk8 also known as Cyclin-dependent kinase 8 or CDC2L6 is a member of the cyclin-dependent kinase family. It has a molecular mass of approximately 50 kDa. Cdk8 primarily functions as a kinase regulating various stages of transcription by phosphorylating components of the transcriptional machinery. It is ubiquitously expressed in multiple tissues indicating its broad range of functions within the cellular environment.
Biological function summary
The activity of Cdk8 integrates into critical processes involving cellular growth and gene expression. Cdk8 forms a part of the Mediator complex alongside cyclin C MED12 and MED13 regulating transcriptional initiation. This kinase plays a role in the modulation of RNA polymerase II activity with its regulation affecting diverse gene expression patterns within the cell.
Pathways
Cdk8 participates significantly in Wnt/β-catenin and MAPK signaling pathways. Its involvement in the Wnt pathway affects cellular proliferation and differentiation with implications for development and tumorigenesis. Related proteins within these pathways include β-catenin and MAPK which interact closely with the regulatory functions governed by Cdk8 to ensure proper signaling transduction.
Cdk8 has strong associations with cancer and developmental disorders. Dysregulation of Cdk8 activity is often observed in colorectal cancer making it a potential target for cancer therapy. In developmental disorders Cdk8's interaction with proteins in the Mediator complex links it to congenital malformations. This highlights its importance in both tumorigenesis and normal developmental processes.