Abcam, ab287089, AMG-510

Size: 1mg / 5mg
MW 560.6 Da, Purity >98%. An orally available agent that targets the specific KRAS mutation, p.G12C, with potential anti-neoplastic activity. Upon oral administration, KRAS mutant-targeting AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents the expression of and/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells.
Key facts
CAS number:2252403-56-6,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:560.6 Da,
Molecular formula:C30H30F2N6O3,
PubChem:137278711,
Nature:Synthetic,
Solubility:DMSO,
Biochemical name:Sotorasib,
Biological description:An orally available agent that targets the specific KRAS mutation, p.G12C, with potential anti-neoplastic activity. Upon oral administration, KRAS mutant-targeting AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents the expression of and/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells.,
Canonical smiles:CC1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C,
Isomeric smiles:C[C@H]1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C,
InChi:InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1,
InChiKey:NXQKSXLFSAEQCZ-SFHVURJKSA-N,
IUPAC Name:6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B2558 AMG-510. B2558-5 is the same size as the 5 mg size of ab287089.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark