Abcam, ab287098, Furamidine dihydrochloride

Size: 5mg / 25mg
MW 304.3 Da, Purity >98%. A potent, selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor (IC 50 = 9.4 μM). Displays selectivity over PRMT5, PRMT6 and CARM1 (IC 50 values are 166, 283 and >400 μM respectively). Inhibits cell proliferation in leukemia cell lines.
Key facts
CAS number:73819-26-8,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:304.3 Da,
Molecular formula:C18H16N4O,
PubChem:126437,
Nature:Synthetic,
Solubility:>15 mg/ml in Water>15 mg/ml in DMSO,
Biochemical name:Furamidine,
Biological description:A potent, selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 μM). Displays selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and >400 μM respectively). Inhibits cell proliferation in leukemia cell lines.,
Canonical smiles:C1=CC(=CC=C1C2=CC=C(O2)C3=CC=C(C=C3)C(=N)N)C(=N)N,
InChi:InChI=1S/C18H16N4O/c19-17(20)13-5-1-11(2-6-13)15-9-10-16(23-15)12-3-7-14(8-4-12)18(21)22/h1-10H,(H3,19,20)(H3,21,22),
InChiKey:ZJHZBDRZEZEDGB-UHFFFAOYSA-N,
IUPAC Name:4-[5-(4-carbamimidoylphenyl)furan-2-yl]benzenecarboximidamide

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B2581 Furamidine dihydrochloride. B2581-25 is the same size as the 25 mg size of ab287098.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Protein Arginine Methyltransferase 1 (PRMT1) Tyrosyl-DNA Phosphodiesterase 1 (TDP1) and NAD(P)H quinone dehydrogenase 2 (NQO2) are distinct yet significant biological targets. PRMT1 also known as HRMT1L2 is a methyltransferase enzyme with a molecular mass of approximately 42 kDa expressed widely across tissues. TDP1 recognized by its unique capability to repair DNA is found in the nucleus and weighs around 68 kDa. NQO2 functions as a flavoprotein located in the cytosol with a molecular mass of 25 kDa. Although these proteins have different roles they involve critical biochemical activities in cells.
Biological function summary
Protein Arginine Methyltransferase 1 modifies histones by methylating arginine residues affecting gene expression. PRMT1 often interacts with other proteins to form complexes that regulate transcription. TDP1 is essential in rescuing stalled topoisomerase I-DNA complexes by cleaving DNA-tyrosyl covalent linkages playing a role in DNA repair. NQO2 interacting with several cellular compounds protects cells by reducing orthoquinone substrates contributing to antioxidant defenses. This collaboration with other proteins enhances the cell's ability to maintain genomic integrity and regulate stress responses.
Pathways
PRMT1 is involved with the methylation pathway influencing gene regulation linked to arginine metabolism alongside proteins like PRMT5. TDP1 functions in the DNA repair pathways specifically the single-strand break repair mechanism working closely with proteins such as XRCC1. NQO2 is part of the detoxification pathway contributing to the cellular response to oxidative stress and working in concert with quinone reductase pathways. These pathways establish the important connections among these proteins and their partners driving essential cellular functions.
Altered PRMT1 expression connects to cancer as dysregulation can lead to abnormal cell growth in tumors. Alterations in TDP1 levels are linked to neurodegenerative disorders especially those related to neuronal DNA damage and often interact with proteins like Parkin. The role of NQO2 is significant in Parkinson’s disease where it affects dopamine metabolism. These proteins highlight the intersection between biochemical pathways and pathologies emphasizing the importance of understanding their functions in disease contexts.