Abcam, ab288228, Anti-Envelope Glycoprotein antibody [7H7] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal VGP antibody. Carrier free. Suitable for ICC, WB and reacts with Transfected cell line, Zaire ebolavirus samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:7H7,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Zaire ebolavirus,
Applications:WB, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:Zaire Ebola virus

Product details:
Partially humanised (rabbit scFv, human IgG1 Fc).
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 6Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The envelope glycoprotein also known as the viral envelope protein plays an important role in the life cycle of viruses. This glycoprotein sometimes referred to as HSV glycoprotein is essential for the viral entry into host cells. The envelope glycoprotein has a mass that typically ranges between 70 to 180 kDa depending on the virus species. It is expressed on the surface of various viruses where it facilitates the fusion between the virus and the host cell at a critical entry point for infection.
Biological function summary
The function of membrane-bound proteins like the envelope glycoprotein involves mediating interactions between the virus and host cell receptors. This glycoprotein is a component of the viral envelope complex which includes other proteins necessary for proper viral assembly and release. It assists in the recognition and binding of specific receptors on the host cell membrane initiating the fusion process. This fusion is a necessary step for the entry of viral nucleic acids into the host cell therefore beginning the infection process.
Pathways
Scientists study how proteins like the envelope glycoprotein participate in viral pathogenicity pathways. The viral entry pathway involves the interaction of envelope glycoproteins with host cell surface receptors such as heparan sulfate proteoglycans. This interaction triggers a cascade of events leading to endocytosis and subsequent release of viral genetic material into the cell. Other proteins such as the G-protein-coupled receptor (GPCR) also play roles in modulating the cellular environment to benefit the virus.
Research identifies the envelope glycoprotein as important in the pathogenesis of conditions like herpes simplex virus (HSV) infections and other virus-caused disorders. HSV glycoproteins help the virus to evade the immune system contributing to the persistent nature of the infection. The envelope glycoprotein also connects to various viral proteins that modulate immune signaling pathways like the latency-associated nuclear antigen (LANA) in specific viral strains cementing its role in ongoing and chronic infection.