Abcam, ab288766, Anti-CACNA1E antibody [EPR25385-129]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal CACNA1E antibody. Suitable for IHC-P, Flow Cyt (Intra), IP, WB and reacts with Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25385-129,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Mouse,
Applications:IP, Flow Cyt (Intra), WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The CACNA1E gene encodes the alpha-1E subunit of voltage-dependent calcium channels also known as Cav2.3. These channels play a role in mediating the influx of calcium ions into excitable cells. The molecular mass of the CACNA1E-encoded protein is approximately 250 kDa. Expressed widely throughout the nervous system particularly within the brain and various neurons the protein facilitates calcium ion conductance important for neuronal activity.
Biological function summary
Cav2.3 channels contribute to neurotransmitter release neuronal excitability and synaptic plasticity. They serve as integral parts of the high-voltage activated calcium channel complex sharing this role with other similar channels. Their function has implications for excitatory synaptic transmission and the modulation of neuronal circuits.
Pathways
The CACNA1E-related channels integrate into both the calcium signaling and neurotransmitter release pathways. These pathways are essential for the propagation of signals in neurons and synapses. The CACNA1E protein is related to other calcium channel alpha subunits like Cav2.1 (CACNA1A) and Cav2.2 (CACNA1B) which collectively orchestrate calcium influx necessary for neurotransmitter exocytosis.
Abnormal function or expression of these channels connects to epilepsy and certain types of migraine. Mutations in CACNA1E may alter channel function impacting calcium ion homeostasis within neurons. Related proteins such as those encoded by CACNA1A have been implicated in similar neurological disorders reflecting a shared involvement within critical neural circuits.