Abcam, ab289635, Anti-SLC5A7 antibody [EPR25152-16]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal SLC5A7 antibody. Suitable for ICC/IF, WB, Flow Cyt (Intra) and reacts with Mouse, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25152-16,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:ICC/IF, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLC5A7 also known as the choline transporter-like protein 1 (CHT1) functions as a sodium-dependent high-affinity choline transporter. This transporter has a mass of around 68 kDa and is part of the solute carrier family 5. SLC5A7 mainly expresses in the nervous system especially in cholinergic neurons. It plays a critical role in the uptake of choline into these neurons which is essential for subsequent acetylcholine synthesis.
Biological function summary
SLC5A7 is integral to the production and storage of acetylcholine an important neurotransmitter involved in synaptic transmission. It does not function as part of any larger known protein complex but stands alone as a transporter. Acetylcholine is essential for normal cognitive function neuromuscular junction operation and autonomic nervous system regulation. The ability of SLC5A7 to transport choline directly influences the availability of acetylcholine making it a significant element in neurotransmission processes.
Pathways
SLC5A7 plays a major role in the cholinergic signaling pathway. It connects very closely with the enzyme choline acetyltransferase which catalyzes the synthesis of acetylcholine from choline. Another relevant pathway is the acetylcholine biosynthetic pathway where SLC5A7 regulates choline availability. The choline taken up by SLC5A7 becomes acetylcholine linking it functionally to these pathways and emphasizing its importance in choline metabolism and neurotransmitter synthesis.
Disruptions in SLC5A7 function connect with various neurological conditions such as congenital myasthenic syndrome and Alzheimer's disease. Congenital myasthenic syndrome can arise from mutations affecting SLC5A7 leading to impaired acetylcholine availability at the neuromuscular junction causing muscle weakness. In Alzheimer's disease reduced cholinergic function partly due to impaired SLC5A7 activity has been observed. SLC5A7 also interacts with components like vesicular acetylcholine transporter within the disease context highlighting its significance in maintaining normal neuronal function and integrity.