Abcam, ab289849, PD-0325901, Sterile-Filtered

Size: 1mL
PD-0325901 (ab289849) is a selective and ATP non-competitive MEK1/2 inhibitor that suppresses phosphorylation of ERK in murine colon 26 tumors (IC50 = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells.
Key facts
CAS number:391210-10-9,
Purity:>98%,
Form:LiquidSee storage information,
Molecular weight:482.19 g/mol,
Molecular formula:C16H14F3IN2O4,
Nature:Synthetic,
Biological description:Selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC50 = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells.,
Canonical smiles:C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O,
InChi:InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1,
InChiKey:SUDAHWBOROXANE-SECBINFHSA-N,
IUPAC Name:N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide

Product details:
5mM sterile-filtered solution in DMSO.
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Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes