Abcam, ab2899, Anti-beta COP antibody

Size: 100µL
Rabbit Polyclonal beta COP antibody. Suitable for ICC/IF, IP, WB and reacts with Mouse, Rat, Primates, Hamster, Human, Cow samples. Cited in 52 publications. Immunogen corresponding to Synthetic Peptide within Rat Copb1 aa 450-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human, Primates, Cow, Hamster,
Applications:IP, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Rat Copb1 aa 450-550. The exact immunogen used to generate this antibody is proprietary information.P23514

Properties and Storage Information:
Form-Liquid, Purification technique-Precipitation Ammonium Sulphate, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Beta COP also known as coatomer subunit beta and sometimes referred to as beta COPI is an important component of the coatomer protein complex involved in vesicle formation and trafficking. This protein has a molecular mass of approximately 110 kDa. Beta COP is expressed widely across various tissues and is essential in maintaining cellular transport systems. It resides mainly within the cytosolic coat of COPI vesicles that originate from Golgi membranes helping in directing the flow of enzymes that are vital for cellular metabolism.
Biological function summary
Coatomer subunits like beta COP play an integral role in forming the COPI complex which functions as a coat on Golgi-derived transport vesicles. Beta COP acts to mediate retrograde transport from the Golgi apparatus back to the endoplasmic reticulum. By helping in vesicle budding and fusion processes it ensures correct protein sorting and localization. This mechanism is critical for cellular homeostasis and proper cellular functions.
Pathways
The COPI-mediated transport involving beta COP plays a significant role in the Golgi-to-ER retrograde transport pathway. This pathway is vital for maintaining the balance of lipids and proteins within cells. Key proteins interacting with this pathway include other coatomer subunits such as delta and gamma COP. Through these interactions beta COP is indispensable in regulating vesicle trafficking and membrane dynamics affecting overall cellular communication.
Beta COP's malfunction can lead to disruptions in vesicle transport potentially contributing to disorders like genetic syndromes or neurodegenerative diseases. Research suggests a connection between aberrant COPI transport and pathology such as Parkinson's disease where beta COP might interact with protein alpha-synuclein. Additionally alterations in beta COP's function link to Alzheimer’s disease where its dysfunction could impact amyloid precursor protein processing. Understanding these connections offers pathways to exploring therapeutic interventions.