Abcam, ab289975, Anti-HCF-1 / Host Cell Factor C1 antibody [EPR25290-18]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal HCF-1 / Host Cell Factor C1 antibody. Suitable for ICC/IF, WB, Flow Cyt (Intra), IHC-P and reacts with Mouse, Human, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25290-18,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Mouse, Human,
Applications:ICC/IF, Flow Cyt (Intra), IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Host Cell Factor C1 commonly known as HCF-1 is a large protein with a mass of approximately 203 kDa. It is widely expressed in many tissues and it plays a significant role in cellular processes such as transcription regulation. HCF-1 can be commonly found in the nucleus and cytoplasm and through various alternative names it is sometimes referred to as HCF-1 HCF-1 stores or HCP48BCF. Its mechanical action involves the regulation of transcription through interactions with other transcription factors and cofactors.
Biological function summary
In multiple cellular frameworks HCF-1 operates as a part of the Set1/COMPASS complex which is pivotal for transcriptional coactivation. It engages in the regulation of cell cycle progression acting as a co-regulator with transcription factors associated with cell proliferation. HCF-1 influences chromatin structure permitting changes in gene expression. This dynamic regulation facilitates processes like DNA replication and repair emphasizing its role in maintaining genomic stability.
Pathways
Several cellular pathways involve HCF-1 including the herpes simplex virus (HSV) replication pathway and the E2F transcriptional pathway. In the HSV pathway HCF-1 interacts with viral components to regulate gene expression. In the context of E2F pathways HCF-1 links with E2F transcription factors to control cell cycle entry and progression. Such interactions highlight its central role in coordinating cellular responses to both internal and external stimuli.
HCF-1 connections arise prominently in cancer and neurodevelopmental disorders. Its deregulation is often seen in cancer where it can interact with oncoproteins such as c-Myc modulating oncogenic transcription. HCF-1's role in transcriptional regulation and chromatin remodeling ties it to neurodevelopmental disorders where associated proteins like SETD1A are critical. Understanding these connections highlights the therapeutic potential of targeting HCF-1 in disease contexts.