Abcam, ab290478, Human SDC4 knockout PC-3 cell line

Size: 1000000Cells / vial / 2 x 1000000Cells / vial
SDC4 KO cell line available to order. KO validated by Next Generation Sequencing. Free of charge wild type control available. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:PC-3,
Species or organism:Human,
Tissue:Prostate,
Form:LiquidSee storage information,
Knockout validation:Next Generation Sequencing,
Disease:Adenocarcinoma

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-SDC4, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Next Generation Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Syndecan 4 also known as SDC4 is a transmembrane heparan sulfate proteoglycan with a molecular mass of around 30 kDa. It functions mechanically by interacting with the extracellular matrix via its heparan sulfate chains which are critical for binding growth factors and other matrix molecules. Syndecan 4 is ubiquitously expressed in many cell types including fibroblasts and epithelial cells playing a role in cell adhesion and migration.
Biological function summary
Syndecan 4 contributes to cell signaling and cytoskeletal organization. This proteoglycan acts as an essential co-receptor for various growth factors facilitating their interaction with their receptors on the cell surface. By doing so it supports cell proliferation and repair processes and it's also known to interact with integrins to modulate cell adhesion. Syndecan 4 does not function alone; it forms part of complexes with other cell surface receptors and interacts with key signaling molecules inside cells.
Pathways
Syndecan 4 is integral in the regulation of several signal transduction pathways such as the protein kinase C (PKC) and Rho family GTPase pathways. These pathways are essential for modulating cellular responses to mechanical stress and changes in the extracellular environment. Syndecan 4 works closely with proteins such as fibronectin and integrins within these pathways to distribute mechanical signals appropriately across the cell membrane linking the extracellular matrix to intracellular processes.
Syndecan 4 has strong associations with conditions like cancer and arthritis. In cancer altered Syndecan 4 expression can impact tumor cell proliferation and metastasis often in concert with matrix metalloproteinases which remodel the extracellular matrix environment to facilitate invasion. In arthritis Syndecan 4 plays a role in inflammatory processes where its interactions with cytokines and other cell-surface proteins can influence cartilage degradation and joint inflammation.