Abcam, ab290685, Anti-MTA1 antibody [EPR24507-64] - BSA and Azide free (Detector)

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal MTA1 antibody. Carrier free. Suitable for sELISA and reacts with Mouse, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24507-64,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Human,
Applications:sELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab290685 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human and Mouse MTA1. The recommended pair for sandwich ELISA is:
Capture:
ab290684
, Human and Mouse MTA1 Capture Antibody (unconjugated)
Detector: ab290685, Human and Mouse MTA1 Detector Antibody (unconjugated)
The reference range value is 0.156-10 ng/mL.
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MTA1 protein short for Metastasis-Associated 1 is a significant player in cellular mechanisms. It has an approximate molecular weight of 80 kDa. MTA1 is known for its function as a chromatin remodeling factor involved in altering chromatin structure to regulate gene expression. Alternate names include metastasis tumor antigen 1. MTA1 expresses widely but has higher levels in metastatic tumor cells playing a role in cancer progression by influencing gene transcription and chromatin dynamics.
Biological function summary
MTA1 contributes to regulating diverse cellular processes. It forms part of the NuRD complex which plays a critical role in mediating chromatin remodeling and histone deacetylation. This association enables MTA1 to influence key aspects of cellular behavior including cell proliferation differentiation and response to stress. The protein's involvement extends to modulating transcription factors and interacting with several other proteins impacting cellular growth and metastasis.
Pathways
MTA1 participates actively in the regulation of several key signaling networks. One significant pathway is the Wnt/β-catenin signaling pathway where MTA1 modulates gene expression by interacting with β-catenin. In another pathway it affects the estrogen receptor signaling pathway impacting gene transcription in hormone-dependent cancers. MTA1’s interaction with HDAC (Histone deacetylase) proteins emphasizes its role in epigenetic regulation across different biological pathways.
MTA1 is frequently connected with cancer progression and metastasis. Its overexpression correlates with poor prognosis in breast cancer highlighting its impact on tumor aggressiveness. Additionally MTA1 has implications in prostate cancer where it interacts with the androgen receptor influencing cancer cell proliferation and resistance to therapy. Understanding the role of MTA1 in these diseases could potentially lead to new therapeutic targets for cancer treatment.