Abcam, ab300441, Anti-LHX6 antibody [EPR26352-101]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal LHX6 antibody. Suitable for IHC-P and reacts with Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26352-101,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LHX6 also known as LIM homeobox 6 acts as a transcription factor in the body. This protein has a molecular mass of about 44 kDa. LHX6 is expressed in specific regions of the brain especially in the developing and mature basal forebrain. Its expression is also noted during the early stages of embryogenesis indicating its role in development.
Biological function summary
The function of LHX6 centers around the regulation of cell differentiation particularly in neural progenitor cells. It does not function alone but operates as a part of a complex with other transcription factors influencing the development and migration of interneurons. LHX6 is pivotal for the specification of GABAergic interneurons which are essential for maintaining the balance of excitation and inhibition in the nervous system.
Pathways
LHX6 plays roles in several critical signaling pathways. It influences the Wnt signaling pathway which is key for cell differentiation. LHX6 also interacts with proteins like NKX2-1 and DLX1/2 participating in the pathway that determines interneuron fate. These interactions highlight its importance in directing the fate of neural cells during development.
Mutations or altered expression of LHX6 have associations with neurological conditions such as epilepsy and schizophrenia. Dysfunction in Wnt signaling in which LHX6 is involved can contribute to the pathogenesis of schizophrenia. Furthermore LHX6 may interact with protein pathways involving NKX2-1 with implications in the development of epilepsy emphasizing its significance in maintaining normal neural function.