Abcam, ab302492, Anti-RILPL1 antibody [MJF-R41-21]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal RILPL1 antibody. Suitable for IP, ICC/IF, WB and reacts with Rat, Mouse, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:MJF-R41-21,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:ICC/IF, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Collaborations
This antibody was developed with support from The Michael J. Fox Foundation.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RILPL1 also known as Rab interacting lysosomal protein-like 1 is a protein involved in cellular processes related to lysosomal trafficking. It has a molecular weight of approximately 45 kDa. RILPL1 expresses itself in a variety of tissues notably in the brain. The protein plays a significant role in intracellular transport mechanisms specifically in modulating the interaction between lysosomal structures and other cellular components.
Biological function summary
RILPL1 influences neuronal functions and is implicated in the regulation of ciliogenesis and other cellular morphogenesis processes. It often associates with components of the cytoskeletal network acting within protein complexes that contribute to cell shape and stability. This involves aiding in processes like axon transport which is critical for maintaining neuronal connectivity and function across different regions of the brain.
Pathways
RILPL1 is a part of cellular pathways involving lysosome positioning and transport. It interacts with motor proteins such as dynein and kinesin essential for microtubule-based movement. RILPL1's role in these pathways highlights its contribution to maintaining lysosomal homeostasis and transportation impacting processes like autophagy and endocytosis.
RILPL1 has been linked to neurodegenerative diseases like Huntington’s disease where disruption of lysosomal trafficking can lead to cellular pathology. The protein's interaction with the Huntingtin protein suggests its involvement in pathways that when dysregulated contribute to disease progression. Additionally irregularities in RILPL1 function may relate to ciliopathies disorders affecting cilia formation and function due to its role in driving key processes in neuronal cells.