Abcam, ab302622, Anti-MUPP1 antibody [EPR26317-59] (BSA and Azide free)

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Mupp1 antibody. Carrier free. Suitable for IP, Flow Cyt (Intra), ICC/IF, IHC-Fr, IHC-P, WB and reacts with Rat, Human, Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26317-59,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human, Mouse, Rat,
Applications:IHC-P, IHC-Fr, Flow Cyt (Intra), ICC/IF, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MUPP1 also known as multi-PDZ domain protein 1 or MPDZ functions as a scaffolding protein that contains multiple PDZ domains. This protein features a mass of about 200 kDa. It gets expressed mainly in epithelial tissues including the brain and kidney. MUPP1 localizes to cell junctions where it interacts with various membrane proteins to organize cellular complexes.
Biological function summary
MUPP1 plays a role in cellular signaling and maintaining integrity of tight junctions. It participates in forming multi-protein complexes that help regulate processes like cell polarity and signal transduction. The protein binds with other PDZ domain-containing proteins influencing ion channels and receptors' function and stability in cells.
Pathways
MUPP1 interacts with several proteins that are part of the epithelial cell signaling pathway. It connects with proteins such as claudins and occludins playing a role in tight junction assembly and maintenance. Additionally its interaction with receptors like serotonin receptors suggests involvement in signaling pathways associated with neurotransmitter transport and cellular response.
MUPP1 has been linked to conditions like ischemic stroke and hearing loss. Alterations in MUPP1 expression or function affect the stability and integrity of tight junctions impacting conditions where barrier function is essential. Disruption in associated proteins like claudins can lead to compromised barrier function in ischemic strokes while interactions with synaptic proteins might contribute to auditory system disorders.