Abcam, ab302713, Anti-GLTSCR1 antibody [EPR26561-76] (BSA and Azide free)

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal GLTSCR1 antibody. Carrier free. Suitable for Flow Cyt (Intra), ICC/IF, IHC-P, WB and reacts with Mouse, Human, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26561-76,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Rat, Mouse, Human,
Applications:WB, IHC-P, Flow Cyt (Intra), ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GLTSCR1 also known as Glioma Tumor Suppressor Candidate Region Gene 1 is a protein that functions in chromatin remodeling. This protein plays an important role in regulating gene expression by impacting chromatin structure making genes accessible or inaccessible as needed. The molecular mass of GLTSCR1 is approximately 110 kDa. Expression of GLTSCR1 happens in various human tissues with notable presence in brain tissues where it might influence neurological functions.
Biological function summary
GLTSCR1 operates as part of the larger BAF chromatin remodeling complex which is vital for modifying chromatin architecture. This complex aids transcription regulation and helps control cellular differentiation. The protein acts to influence the organization of chromatin which can lead in turn to the activation or repression of certain genes. This function positions GLTSCR1 as an important player in maintaining cellular homeostasis and determining cell fate.
Pathways
GLTSCR1 is key in transcriptional regulation pathways and plays a role in neural development. The protein interacts with other components within the BAF complex like BRG1 and BAF155 thereby exerting influence across pathways linked to DNA accessibility and transcription. Its activity can impact pathways such as the Wnt signaling pathway where its chromatin remodeling capabilities interface with signal transduction processes influencing cell division and development.
Aberrations in GLTSCR1 are linked to glioblastoma multiforme and neurodevelopmental disorders. In glioblastoma disruptions in chromatin remodeling and gene expression can lead to uncontrolled cell growth. The disorder may involve interactions with other protein complexes including ones containing MLL1 involved in histone modification suggesting a wide-net impact on epigenetic regulation. Additionally its association with the nervous system development links it to certain neurodevelopmental anomalies indicating its broader significance in maintaining nervous system integrity.