Abcam, ab302917, Anti-VLDL Receptor/VLDL-R antibody [EPR26178-72]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal VLDL Receptor/VLDL-R antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26178-72,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The VLDL Receptor also known as VLDL-R mediates the uptake of very low-density lipoproteins (VLDLs) into cells. This receptor has a molecular mass of approximately 104 kDa. It is structurally similar to the low-density lipoprotein (LDL) receptor and binds to apolipoprotein E-containing lipoproteins. VLDL-R expresses in several tissues including heart skeletal muscle and adipose tissue. Its distribution suggests an important role in lipid metabolism for energy production and storage.
Biological function summary
VLDL-R significantly influences lipid and lipoprotein metabolism by facilitating the endocytosis of triglyceride-rich particles. It functions within the larger receptor family known as the LDL receptor family. VLDL-R plays an important role in cellular lipid uptake and the subsequent supply of fatty acids which are necessary for various metabolic processes. This receptor does not function as part of a protein complex but its interactions with other proteins can alter its activity and the cell's metabolic state.
Pathways
This receptor influences lipid metabolism and energy homeostasis pathways. It directly impacts the lipid biosynthetic pathway by mediating the cellular uptake of lipid components necessary for these processes. The receptor interacts with proteins like apolipoprotein B and E which regulate lipoprotein assembly and clearance. In this pathway VLDL-R works conjunctionally with the LDL receptor to maintain lipid balance within the body.
VLDL-R relates to metabolic syndrome and obesity. Abnormalities in VLDL-R function can lead to dyslipidemia a risk factor for these conditions due to the mishandling of lipid uptake. This association connects VLDL-R to apolipoprotein E and B whose mutations can also contribute to these metabolic disorders. Understanding how VLDL-R operates in these contexts may provide insight into therapeutic targets for these widespread health issues.