Abcam, ab302924, Anti-UNC5C antibody [EPR24190-37]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal UNC5C antibody. Suitable for WB and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24190-37,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UNC5C also known as Unc-5 Netrin Receptor C serves as a receptor for netrin a protein that guides axonal growth. It is a member of the UNC5 family and plays an important role in cell migration and positioning. The molecular mass of UNC5C is approximately 103 kDa. It is mainly expressed in the nervous system specifically in the developing brain and spinal cord but can also be found in other tissues to a lesser degree. Its expression pattern suggests a role diverse from just the nervous system.
Biological function summary
UNC5C functions significantly in neuronal guidance and apoptosis regulation. It forms part of a receptor complex together with DCC (Deleted in Colorectal Carcinoma) when binding with netrin-1 another important protein in axon guidance. This interaction influences neuronal cells’ behavior by repelling or attracting axons depending on the context. Beyond its interaction with netrin-1 UNC5C also engages in signaling pathways promoting or inhibiting cell death adding to its versatile functions in cellular processes.
Pathways
UNC5C participates in the axon guidance and apoptotic processes. It plays an important role in the netrin signaling pathway by interacting with DCC and netrin-1 helping to steer neuron growth cones during development. Additionally it has involvement with the apoptosis pathway where UNC5C interactions can lead to programmed cell death when certain conditions are met such as absence of netrin-1. The protein's function is intricately linked with others like DCC and the netrin family which means it influences and is influenced by key neurodevelopmental pathways.
Mutations or dysregulation of UNC5C have been associated with neurodegenerative conditions and cancer. Altered UNC5C signaling can contribute to the progression of Alzheimer's disease potentially through the disruption of normal axonal pathfinding or neuronal death mechanisms. In cancer particularly colorectal cancer UNC5C acts as a dependence receptor where its malfunction can trigger inappropriate cell survival contributing to tumorigenesis. UNC5C’s interaction with DCC highlights its role in colorectal cancer emphasizing how its impairment can promote the escape from normal apoptotic signals.