Abcam, ab302939, Anti-Influenza A H7N9 Neuraminidase antibody [10F4] - BSA and Azide Free

Size: 100µg / 1mg
Mouse Recombinant Monoclonal Influenza A H7N9 Neuraminidase antibody. Carrier free. Suitable for ICC/IF, I-ELISA and reacts with Transfected cell line - Influenza A, Influenza A samples.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:10F4,
Isotype:IgG1,
Carrier free:Yes,
Reacts with:Influenza A,
Applications:I-ELISA, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab302939 is a carrier free version of
ab302938
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Influenza A H7N9 Neuraminidase also known as NA or sialidase is an enzyme important in the viral replication process of the influenza virus. This protein with a molecular mass of approximately 47 kDa is expressed on the surface of the influenza A virus particles. Neuraminidase facilitates the removal of sialic acid residues from glycoproteins and glycolipids which is essential for the release of new viral particles from infected host cells. The enzymatic action is an important factor in the virus's spread within the respiratory tract of the host organism.
Biological function summary
The action of Influenza A H7N9 Neuraminidase assists in the completion of the viral life cycle. Neuraminidase in conjunction with hemagglutinin is part of a complex that allows the virus to attach and penetrate host cells efficiently. By cleaving sialic acid residues neuraminidase enables the newly formed viral particles to detach and spread facilitating infection progression. This protein's ability to disrupt cellular interactions highlights its role in viral pathogenicity an essential feature for the influenza virus's survival in host organisms.
Pathways
Neuraminidase plays a significant part in the influenza viral entry and propagation pathways. Its interaction with hemagglutinin is important for the entry of the virus into host cells. Neuraminidase's activity supports the recycling of viral particles therefore contributing to the greater viral lifecycle network. Additionally its function links with pathways of immune evasion where it helps in avoiding the host's immune response primarily through altering host cell surface molecules and aiding in the spread of infection.
Neuraminidase is closely associated with the pathogenesis of influenza particularly with influenza A and its subtypes such as H7N9. Neuraminidase inhibitors like oseltamivir target this protein to prevent the spread of influenza virus and mitigate symptoms. Resistance to such inhibitors can arise making the study of neuraminidase important for developing effective treatments. Neuraminidase's activity affects both the viral lifecycle and the host's immune response underlining its role in the interactions between influenza virus proteins and host immune components.