Abcam, ab303534, Anti-PRDM16 antibody [EPR24315-59]

Size: 20µL / 100µL / 1mL
Anti-PRDM16 antibody [EPR24315-59] is a Rabbit Monoclonal antibody that is used in PRDM16 Western Blot. Suitable for Human, Mouse samples. PRDM16 is a transcription coregulator that controls the development of brown adipocytes in brown adipose tissue. It also plays a role in the differentiation of beige adipocytes and is involved in chromatin organization
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24315-59,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PRDM16 also known as the PR-domain containing 16 is a transcription cofactor involved in the regulation of genes. It has a mass of approximately 140 kDa. This protein is found in multiple tissues with high expression levels observed in brown adipose tissue and skeletal muscle. PRDM16 regulates gene expression by interacting with other transcription factors and modifying chromatin structure.
Biological function summary
PRDM16 is essential in the determination of brown adipose tissue and skeletal muscle differentiation. It belongs to a complex that includes C/EBPβ and PPARγ which are pivotal for the conversion of myoblasts into thermogenic brown fat cells. This activity contributes to the generation of cells specialized for heat production which aids in maintaining body temperature.
Pathways
PRDM16 functions are linked to cellular metabolism and thermogenesis. It plays a substantial role in the Wnt/β-catenin signaling pathway where it influences energy balance. In this pathway PRDM16 interacts with Wnt signaling regulators and coactivators that control adipocyte differentiation and energy expenditure.
PRDM16 plays a role in myoblastic leukemia and obesity-related conditions. Changes in the function or expression of PRDM16 can contribute to pathological transformation leading to leukemia with proteins C/EBPβ and PPARγ also involved in related mechanisms. In obesity altered PRDM16 activity affects the formation and function of brown adipose tissue potentially disrupting normal energy metabolism and storage.