Abcam, ab307197, Anti-mSin3a antibody [EPR27103-53]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal mSin3A antibody. Suitable for IP, Flow Cyt (Intra), WB and reacts with Human, Rat, Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27103-53,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IP, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MSin3A also known as Sin3A is a transcriptional corepressor that plays an important role in regulating gene expression. It weighs approximately 155 kDa. You can find mSin3A expressed in various tissues throughout the body. This protein does not bind DNA directly but associates with DNA-binding proteins to exert its effects. mSin3A functions mechanically by interacting with histone deacetylases (HDACs) leading to the remodeling of chromatin and repression of gene transcription.
Biological function summary
MSin3A acts to regulate gene silencing and is a component of the mSin3A/HDAC complex. This complex is involved in the control of cell cycle progression differentiation and apoptosis. In cellular processes mSin3A serves as a scaffold binding various proteins to create a platform for gene regulatory functions. Its role in recruiting HDACs to specific genomic locations aids in transcriptional repression affecting many biological processes.
Pathways
MSin3A plays significant roles in the Notch and p53 signaling pathways. These pathways are essential in controlling cell fate decisions and responses to stress. mSin3A partners with HDAC1 and HDAC2 within these pathways facilitating the deacetylation and repression of target genes. In the Notch signaling pathway mSin3A interacts with repressors like CSL while in the p53 pathway it influences p53-dependent transcriptional outcomes by modifying the chromatin state.
MSin3A shows connection to cancer and neurodegenerative diseases. In cancer mSin3A affects tumor suppression through its interaction with p53 playing a role in cell cycle arrest and apoptosis. In neurodegenerative diseases mSin3A deregulation may disrupt chromatin architecture impairing neuronal function. By targeting mSin3A and associated proteins like HDAC1 researchers explore potential therapeutic avenues for these diseases.