Abcam, ab307282, Anti-TAP2 antibody [EPR26237-82]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal TAP2 antibody. Suitable for IP, Flow Cyt (Intra), ICC/IF, IHC-P, WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26237-82,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IP, IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAP2 also known as Transporter 2 ATP Binding Cassette Subfamily B Member has a mass of approximately 76 kDa. It functions as a part of the peptide-loading complex where it plays a mechanical role in transporting antigen peptides into the endoplasmic reticulum. TAP2 is expressed primarily in antigen-presenting cells such as B cells dendritic cells and macrophages. It is an integral membrane protein located in the membrane of the endoplasmic reticulum.
Biological function summary
The TAP2 protein operates as an important component of the immune system by facilitating the processing and presentation of antigens. It partners with TAP1 and forms a heterodimer complex essential for the transportation of peptides that are 8-16 amino acids long. This action is fundamental for the proper presentation of antigens on major histocompatibility complex (MHC) class I molecules which are pivotal in the recognition of infected or abnormal cells by cytotoxic T lymphocytes.
Pathways
The TAP2 protein plays a significant role in the antigen processing and presentation pathways. It directly impacts the MHC class I pathway by aiding in the selection and transport of peptides that bind to MHC class I molecules. TAP2 functions alongside related proteins such as TAP1 and tapasin which help facilitate the loading of these peptides onto MHC class I molecules in the endoplasmic reticulum preparing them for cell surface presentation.
Mutations or deficiencies in the TAP2 gene are associated with bare lymphocyte syndrome type 1 (BLS1) a rare immunodeficiency disorder. This syndrome relates to a shortage of antigen presentation on MHC class I molecules leading to increased susceptibility to viral infections. TAP2 along with its partner protein TAP1 is critical in maintaining regular immune surveillance and any disruption in their function can result in profound immunological consequences including impaired cytotoxic T cell responses.