Abcam, ab307430, Anti-NSUN6 antibody [EPR27179-64]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal NSUN6 antibody. Suitable for IP, ICC/IF, WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27179-64,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, ICC/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NSUN6 also known as NOP2/Sun RNA methyltransferase family member 6 is an RNA-modifying enzyme. It belongs to the NOL1/NOP2/Sun family and is responsible for catalyzing 5-methylcytosine formation on target RNA molecules playing an important role in RNA modification. The molecular mass of NSUN6 is approximately 56 kDa. It is expressed in various tissues but shows higher expression in the liver and skeletal muscle suggesting a potential specialization in these areas.
Biological function summary
NSUN6 contributes to the regulation of cellular processes by modifying RNA molecules. It is not currently identified as part of any known protein complex but significantly influences the stability and function of specific RNA targets. By this action NSUN6 can indirectly affect gene expression and downstream biological activities which might be critical during cellular growth and differentiation.
Pathways
NSUN6 interacts closely with pathways related to RNA processing and modification. It contributes to the epitranscriptomic landscape working alongside proteins such as NSUN2 another methyltransferase to maintain RNA modification balance. This activity impacts broader pathways like those regulating gene expression and protein synthesis exhibiting an interconnected role in fundamental cellular activities.
NSUN6 shows relevance to cancer and neurodevelopmental disorders. Alterations in its normal function could disrupt RNA methylation patterns leading to aberrant gene expression linked to these conditions. NSUN6's functional relationship with NSUN2 another RNA methyltransferase suggests that disruptions in their balance might contribute to these disorders highlighting their potential as targets for therapeutic intervention.