Abcam, ab307497, Anti-RGS1 antibody [HL1402]

Size: 100µL
Rabbit Recombinant Monoclonal RGS1 antibody. Carrier free. Suitable for ICC/IF, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human RGS1.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL1402,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RGS1. The exact immunogen used to generate this antibody is proprietary information.Q08116

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Regulator of G-protein signaling 1 (RGS1) also known as BL34 or 1R20 acts mechanically as a GTPase-activating protein (GAP) for Gα subunits of heterotrimeric G-proteins. This function speeds up the deactivation of G-proteins by converting GTP to GDP effectively stopping signal transduction. RGS1 has a molecular mass of approximately 25 kDa. This protein is mainly expressed in B and T lymphocytes and you can find it in lymphoid tissues such as the spleen and lymph nodes.
Biological function summary
The RGS1 protein modulates immune cell signaling thereby controlling cell migration and positioning. RGS1 plays a role in reducing signaling from chemokine receptors which affects the movement of lymphocytes within tissues. It does not significantly form part of a larger complex mostly acting independently to exert its function within the immune system.
Pathways
The regulatory activity of RGS1 heavily influences the chemokine signaling pathway and the G-protein coupled receptor (GPCR) signaling pathway. These pathways are important for the directional migration and activation of immune cells. Within these pathways RGS1 interacts with related proteins such as CXCR4 and Gα subunits modulating their signaling outputs to regulate immune cell responses.
RGS1 links to autoimmune diseases and certain cancers. It can modulate the immune response in diseases such as multiple sclerosis where its activity may affect immune cell movement and function. Connections also exist between RGS1 and CXCR4 within cancer pathology where altered signaling could contribute to tumor growth and metastasis. By affecting these pathways RGS1 becomes a potential target for therapeutic intervention in related disorders.