Abcam, ab307725, Anti-CAPS2 antibody [EPR27004-72] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal CAPS2 antibody. Carrier free. Suitable for WB, IHC-Fr and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27004-72,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human, Mouse, Rat,
Applications:WB, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CAPS2 also known as Calcium-Dependent Secretion Activator 2 is a protein that facilitates the release of neuropeptides and hormones by enhancing dense core vesicle exocytosis. The molecular mass of CAPS2 is approximately 145 kDa. It is expressed mainly in the brain including areas such as the cerebellum and hippocampus. CAPS2 acts by interacting with SNARE proteins which are essential for vesicle fusion and release processes at synaptic sites.
Biological function summary
The protein CAPS2 plays an important role in synaptic transmission and the regulation of neurotransmitter secretion. It promotes the priming and fusion of vesicles allowing their contents to be released into the synaptic cleft. CAPS2 is often linked with other synaptic and regulatory proteins within a protein complex that orchestrates the efficient release of neurotransmitters and neuropeptides necessary for proper neuronal signaling.
Pathways
CAPS2 takes part in the secretory pathway critical for synaptic activity and signaling in neurons. It interacts with important proteins such as synaptotagmin and Munc13 which are involved in the regulation of vesicle priming and exocytosis. Moreover CAPS2 is implicated in the calcium-dependent pathways that regulate neurotransmitter release enhancing functional communication between neurons.
CAPS2 has been associated with autism spectrum disorders and schizophrenia. Studies indicate altered expression of CAPS2 may disrupt synaptic function potentially leading to these neurological conditions. The protein also interacts with voltage-gated calcium channels which are important for neuronal communication and are often involved in the pathophysiology of these disorders. Understanding CAPS2's involvement in these conditions offers potential targets for therapeutic intervention.