Abcam, ab307822, Anti-Homeobox protein cut-like 1 antibody [EPR26508-67] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Homeobox protein cut-like 1 antibody. Carrier free. Suitable for WB, ICC/IF, IP, IHC-P and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26508-67,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Rat, Human, Mouse,
Applications:WB, ICC/IF, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Homeobox protein cut-like 1 often abbreviated as CUX1 functions as a transcription factor involved in the regulation of gene expression. It has an approximate mass of 110 kDa. CUX1 localizes mainly in the nucleus and is widely expressed in various tissues with higher levels observed in the thymus spleen and testis. This protein plays a significant role in cell cycle progression particularly during the S phase where it aids in DNA replication and repair.
Biological function summary
CUX1 regulates the transcription of genes involved in cell proliferation and differentiation. It forms part of a larger transcriptional complex often interacting with other transcription factors and co-regulators to exert its effects. CUX1 influences several developmental processes including hematopoiesis and neuronal differentiation highlighting its broad involvement in cellular function and development.
Pathways
CUX1 interacts within key signaling pathways such as the Wnt signaling and TGF-beta pathways. It plays a role in modulating the expression of genes controlled by these pathways impacting cell fate and proliferation. CUX1 often cooperates with other proteins such as SMADs in the TGF-beta pathway to execute complex regulatory functions. This partnership highlights the integrative role of CUX1 in cellular signaling networks that maintain homeostasis.
CUX1 has been linked to oncogenesis particularly in cancers such as breast cancer and leukemia. Alterations in CUX1 expression or function can lead to uncontrolled cell proliferation as seen in these cancers. Additionally CUX1 interacts with proteins like TP53 in cancer contexts modulating apoptosis and cellular stress responses. These interactions and effects demonstrate the pivotal involvement of CUX1 in the pathogenesis of certain diseases making it a potential target for therapeutic intervention.