Abcam, ab307997, Anti-IP-10 antibody [RP23040081]

Size: 100µg
Rabbit Multiclonal IP10 antibody. Suitable for ICC/IF and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Multiclonal,
Clone number:RP23040081,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:
- The sensitivity of polyclonal antibodies by recognising multiple epitopes
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
View our range of
recombinant multiclonal antibodies

Properties and Storage Information:
Form-Liquid, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IP-10 also known as CXCL10 is a chemokine with a molecular weight of approximately 8.7 kDa. It functions by binding to the CXCR3 receptor a process that regulates immune responses. IP-10 is expressed in a variety of cells such as monocytes epithelial cells and fibroblasts particularly during inflammatory states. Its expression occurs in response to interferons especially IFN-γ indicating its role in immune system activity.
Biological function summary
The protein functions in the recruitment of immune cells like activated T-cells and NK cells to sites of inflammation or infection. It acts independently and is not known to be part of a larger protein complex. IP-10 plays an important role in promoting inflammation thereby contributing to the host defense mechanisms against microbial pathogens. It participates actively in immune surveillance and responses to various pathogens by attracting the immune cells to where they are needed.
Pathways
The chemokine is integral to the inflammatory response and cellular immune response pathways. Throughout these pathways IP-10 operates alongside various cytokines and chemokines such as CXCL9 and CXCL11 which also bind to the CXCR3 receptor. These proteins together modulate leukocyte movement and activities leading to immunity against pathogens as well as regulation of inflammatory processes.
IP-10 has connections with multiple sclerosis and hepatitis C. In multiple sclerosis elevated IP-10 levels correlate with disease severity and progression involving interactions with other chemokines like MCP-1. For hepatitis C IP-10 helps in mediating liver inflammation and fibrosis linking its activity closely with interleukins such as IL-10. Its elevation in these diseases makes IP-10 a potential biomarker for monitoring disease progression and response to therapy.