Abcam, ab308009, Anti Olig1 antibody [RP 23040252]

Size: 100µg
Rabbit Recombinant Multiclonal OLIG1 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Immunogen corresponding to Synthetic Peptide within Human OLIG1.
Key facts
Host species:Rabbit,
Clonality:Multiclonal,
Clone number:RP 23040252,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human OLIG1. Database linkQ8TAK6

Product details:
What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:
- The sensitivity of polyclonal antibodies by recognising multiple epitopes
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
View our range of
recombinant multiclonal antibodies

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Olig1 also known as oligodendrocyte lineage transcription factor 1 is a protein involved in the development and function of oligodendrocytes cells that form the myelin sheath in the central nervous system. It weighs approximately 30 kDa and is expressed primarily in the brain and spinal cord. The protein plays a fundamental role in the maturation process of oligodendrocyte progenitor cells by regulating the transcription of genes necessary for myelination.
Biological function summary
Olig1 is important in the differentiation of progenitor cells into mature oligodendrocytes. It interacts with other proteins like Olig2 often forming heterodimer complexes that enhance transcriptional regulation. Olig1's regulatory actions influence cellular processes pivotal for maintaining neural integrity and function aiding in the production of myelin which is essential for fast and efficient nerve signal transmission in the central nervous system.
Pathways
Olig1 contributes significantly to the oligodendrocyte differentiation and development pathway as well as the myelination process. It works closely with Olig2 with both proteins being regulated within the Sonic Hedgehog signaling pathway. This pathway is vital for neural cell fate determination and contributes to the development of the nervous system ensuring proper function and communication within central nervous system.
Olig1 plays a role in multiple sclerosis and leukodystrophies where myelination is impaired. Abnormal regulation or expression of Olig1 can lead to demyelination a characteristic feature of these diseases. It is also associated with Olig2 which is similarly implicated in these neurological disorders. Understanding Olig1's involvement opens potential targets for therapeutic approaches in treating diseases affecting myelin and oligodendrocyte function.