Abcam, ab308192, Anti-HGS antibody [HL1730]

Size: 100µL
Rabbit Recombinant Monoclonal HGS antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human, Cat, Dog samples. Immunogen corresponding to Recombinant Fragment Protein within Human HGS.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL1730,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human, Cat, Dog,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HGS. The exact immunogen used to generate this antibody is proprietary information.O14964

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HGS protein also known as hepatocyte growth factor-regulated tyrosine kinase substrate plays a significant role in cellular processes. It has a molecular mass of approximately 82 kDa. You will find HGS expressed broadly especially in epithelial tissues where it contributes to regulating various cellular mechanisms. Alternative names for HGS include HRS and HGS products which reflect its involvement in various signaling pathways and functions.
Biological function summary
The HGS acts as a central player in endosomal sorting and targeting processes. It forms a part of the ESCRT-0 complex important for the degradation of surface receptors as it directs ubiquitinated membrane proteins to lysosomes for degradation. HGS interacts with other proteins in the complex such as STAM (Signal transducing adaptor molecule). This role explains its importance in maintaining proper cellular signaling and balance.
Pathways
The HGS protein participates in the endocytosis and ubiquitin-proteasome pathways. HGS plays a critical role in the degradation of epidermal growth factor receptor (EGFR) by assisting its trafficking to lysosomes. This function ties it to cellular communication and signal transduction particularly related to growth signals. Within these pathways HGS closely interacts with proteins such as the hepatocyte growth factor (HGF) and c-Met playing a regulatory role in signal attenuation.
Aberrations in the HGS function link to cancer and neurodegenerative disorders. Dysregulation of the HGS-mediated pathways can lead to abnormal cell growth and cancer progression particularly in epithelial tissues. Additionally research indicates a connection between HGS dysfunction and Alzheimer's disease as it may influence amyloid-beta processing. Interactions with proteins like EGFR and c-Met suggest that alterations in the HGS activity could have significant implications for disease pathogenesis and progression.