Abcam, ab308206, Anti-Enterovirus 71 VP1 antibody [HL1929]

Size: 100µL
Rabbit Recombinant Monoclonal Enterovirus 71 VP1 antibody. Carrier free. Suitable for WB, sELISA, I-ELISA, ICC/IF and reacts with Enterovirus A71, Transfected cell lysate - Enterovirus A71, Recombinant full length protein - Enterovirus A71, Transfected cell line - Enterovirus A71 samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL1929,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Enterovirus A71,
Applications:I-ELISA, WB, ICC/IF, sELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Enterovirus 71 (EV71) also known as enteroviral VP1 is a significant member of the enterovirus genus. Mechanically EV71 is a small RNA virus with a protein capsid that is important for viral replication and cell infection. The virus is around 30 nm in diameter and the capsid proteins including VP1 play an important role in its structure and function. EV71 is primarily expressed in human tissues that include the gastrointestinal tract and central nervous system. The VP1 protein is essential for receptor recognition and mediates the attachment of the virus to host cells facilitating the entry of the viral RNA into the host cell.
Biological function summary
EV71 infects host cells and hijacks the cellular machinery to replicate itself causing cytopathic effects. The VP1 protein is a critical part of the viral capsid complex and interacts with host cell receptors initiating infection. This process causes the host cell to undergo apoptosis and releases new viral particles perpetuating the infection cycle. EV71 plays a substantial role in disrupting host cellular processes which then leads to notable clinical symptoms.
Pathways
EV71 interacts with host cellular pathways involved in viral replication and immune response. Specifically the virus can affect the signal transduction pathways important for the host's antiviral defenses such as the type I interferon pathway. This interaction allows the virus to evade the immune system temporarily. Additionally EV71 affects the proteasome pathway that includes proteins related to antigen presentation which is essential for an adequate immune response by the host.
EV71 is most notably associated with hand foot and mouth disease and can cause severe neurological complications like encephalitis. The virus can affect young children severely and outbreaks have led to significant health concerns in various regions. EV71 interacts with proteins involved in immune surveillance such as those within the interferon response pathways which play a critical role in the pathogenesis of its related diseases. Understanding this interaction is important for developing therapeutic monoclonal antibodies such as mab979 that can target EV71 infections.