Abcam, ab308391, Anti-Hepatitis D virus Large delta + Small delta protein antibody [HL1055]

Size: 100µL
Rabbit Recombinant Monoclonal Hepatitis D Virus antibody. Carrier free. Suitable for ICC/IF, WB and reacts with Transfected cell line - Hepatitis D virus samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL1055,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Hepatitis D virus,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Hepatitis D Small delta antigen (SDAg) and Large delta antigen (LDAg) are essential proteins of the Hepatitis D virus (HDV) known for their involvement in the virus's replication and pathogenesis. The Small delta antigen weighs approximately 24 kDa and the Large delta antigen is about 195 kDa. These proteins are expressed in the cytoplasm and nucleus of infected liver cells where they perform distinct yet interconnected roles in the life cycle of HDV. SDAg facilitates viral replication while LDAg is important for virion assembly.
Biological function summary
The Hepatitis D antigens Small and Large are part of a dynamic complex that plays a significant role in HDV infection. The Small delta antigen enhances the replication of viral RNA by interacting with the cellular machinery effectively hijacking the host cell's resources. In contrast the Large delta antigen mediates encapsidation processes that lead to the formation of new virions. This functional dichotomy within the antigens highlights their unique contributions to HDV persistence in the host organism.
Pathways
Hepatitis D Small and Large delta antigens interface with cellular pathways that are critical for viral survival and propagation. The interferon signaling pathway is notably affected by these antigens as they manipulate host responses to favor HDV replication. Another impacted pathway includes the RNA interference pathway which is modulated by interactions between delta antigens and cellular proteins like Dicer. These interactions indicate the sophisticated strategies HDV employs to leverage host cellular pathways to its advantage.
The Hepatitis D Small and Large delta antigens are directly tied to Hepatitis D infection a severe form of viral hepatitis that can exacerbate the condition in individuals with concurrent Hepatitis B infection. The presence of LDAg correlates with disease progression and liver damage as it relates to chronic liver diseases such as cirrhosis and hepatocellular carcinoma. These delta antigens also interact with the Hepatitis B surface antigen facilitating virion assembly and enabling the HDV to propagate alongside HBV indicating their contribution to co-infection dynamics.