Abcam, ab308415, Anti-SARS CoV 2 (COVID 19) Membrane antibody [HL1088]

Size: 100µL
Rabbit Recombinant Monoclonal VEMP antibody. Carrier free. Suitable for ICC/IF, WB and reacts with Transfected cell line - SARS-CoV-2 samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within SARS-CoV-2 E.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL1088,
Isotype:IgG,
Carrier free:Yes,
Reacts with:SARS-CoV-2,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within SARS-CoV-2 E. The exact immunogen used to generate this antibody is proprietary information.P0DTC4

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SARS-CoV-2 M protein also known as membrane protein plays an important mechanical role in the virus's life cycle. It is a small protein with a mass of approximately 25 to 30 kilodaltons. It is expressed on the surface of the virus envelope and is highly conserved among coronaviruses. The M protein is integral to assembling new viral particles and facilitates the virus's ability to maintain its structure. It influences the shape and integrity of the viral envelope by interacting with other viral proteins such as the spike protein and the envelope protein.
Biological function summary
The SARS-CoV-2 membrane protein plays a significant role in the viral infection process. It functions to orchestrate the assembly of new virions by localizing at the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). The M protein often interacts with the nucleocapsid (N) protein forming a complex essential for packaging viral RNA. This partnership ensures the virus efficiently assembles and buds from the host cell aiding in the sufficient production of infectious particles.
Pathways
The SARS-CoV-2 M protein stands central in viral pathogenesis. It participates in the formation of the viral replication complex within the host cell. The protein interacts with the spike (S) protein facilitating viral entry into the host by enabling the fusion of the viral and cellular membranes through its role in the ERGIC. Additionally the M protein is involved in pathways related to modulating host immune responses often dampening interferon signaling which is important for the host's initial defense against viral infections.
The SARS-CoV-2 membrane protein is intimately linked to COVID-19 the disease caused by the virus. This protein along with other structural proteins like the envelope (E) protein contributes to the pathogenicity and virulence of the virus impacting disease severity. The M protein also has associations with immune evasion strategies employed by the virus which may lead to more severe respiratory complications in infected patients. Understanding its interactions with the host immune system and other viral proteins sheds light on developing targeted therapeutics and vaccines against COVID-19.