Abcam, ab308503, Anti-MR1 antibody [EPR25671-79] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal MR1 antibody. Carrier free. Suitable for WB, Flow Cyt and reacts with Transfected cell lysate - Human, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25671-79,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MR1 also known as the MR1 receptor or MR1 protein is an important player in the immune system. It weighs around 37 kilodaltons. This protein expresses prominently in many tissues such as the liver lymphoid tissues and the intestine. MR1 binds a range of small molecules derived from vitamin B metabolites. It presents these metabolites to a specific group of immune cells known as mucosal-associated invariant T (MAIT) cells leading to their activation.
Biological function summary
MR1 varies its mechanism by forming complexes with antigens that lack traditional peptide structure. It performs a major role in the immune response particularly through its interactions with MAIT cells. These cells represent an important intersection between innate and adaptive immunity responding rapidly to many pathogen-associated metabolites presented by MR1. This response contributes importantly to host protection especially against microbial infections.
Pathways
MR1 is an integral component in the vitamin B antigen presentation pathway. It interacts significantly with other molecules involved in antigen presentation. MR1's function anchors it within the host-pathogen interaction pathways and connects with proteins like beta-2-microglobulin (β2M) which is important for surface expression. Its activity complements classical MHC pathways although it operates independently in presenting non-peptide antigens.
MR1 contributes to understanding certain autoimmune conditions and infectious diseases. It connects to infectious diseases such as tuberculosis where MAIT cell activation plays a critical role in the immune response. Additionally MR1 has links to inflammatory bowel disease (IBD) a condition where gut microbiota activation of MAIT cells through MR1 may influence the disease outcome. Understanding its role in these diseases can provide insights into how MR1 or related proteins might be targeted for therapeutic interventions.