Abcam, ab308524, Anti-ATP7A antibody [EPR27493-139]

Size: 20µL / 100µL / 1mL
Knockout Tested Rabbit Recombinant Monoclonal ATP7A antibody. Suitable for WB, ICC/IF and reacts with Human, Mouse samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27493-139,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATP7A also known as Menkes protein is a copper-transporting ATPase. It has a molecular weight of approximately 162 kDa. ATP7A helps transport copper within cells by being primarily located in the trans-Golgi network and is also found in the plasma membrane. This protein has significant expression in several tissues especially in the nervous system intestines and connective tissue. ATP7A plays a role in distributing copper to copper-dependent enzymes critical for various cellular processes.
Biological function summary
ATP7A is essential in maintaining copper homeostasis across multiple systems. It is involved in supplying copper to enzymes like lysyl oxidase which is important for connective tissue development. ATP7A does not function as a part of a larger complex but it coordinates closely with cellular mechanisms ensuring appropriate copper levels. Its movement between golgi apparatus and the cell membrane allows for effective intracellular copper management.
Pathways
ATP7A influences copper metabolic pathways and is specifically important in the absorption and distribution of copper. It works with another transporter protein ATP7B to maintain copper balance by exporting excess copper into the bile and plasma. Both proteins are critical in copper regulation and show complementary functions in preventing copper toxicity.
ATP7A is closely associated with Menkes disease a disorder characterized by defective copper absorption and distribution leading to developmental delays and connective tissue abnormalities. Another related condition is Occipital Horn Syndrome which involves mutations in ATP7A. These diseases highlight ATP7A's key role in copper transport and highlight its interaction with ATP7B in copper homeostasis directly linking these proteins to the pathology of the disorders.