Abcam, ab309135, Anti-Spinophilin/Neurabin 2 antibody [EPR26265-105]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Spinophilin/Neurabin 2 antibody. Suitable for IHC-P, IHC-Fr and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26265-105,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IHC-Fr, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Spinophilin also known as Neurabin 2 is a protein with a molecular weight of approximately 120 kDa. This protein is mostly found in the central nervous system where it associates with dendritic spines of neurons. Spinophilin contains an actin-binding domain a PDZ domain and a coiled-coil domain which allows it to interact with various proteins involved in synaptic function. Its distribution is not limited to the brain as it has also been identified in other tissues like the liver and kidneys.
Biological function summary
Spinophilin functions in the regulation of synaptic signaling and structural plasticity contributing to neural communication. It often forms part of signaling complexes binding to protein phosphatase 1 (PP1) to modulate dephosphorylation activities. Spinophilin influences the organization and dynamics of actin filaments affecting the stability and morphology of dendritic spines which are critical sites for synaptic transmission and plasticity. Through these interactions Spinophilin plays an important role in learning and memory processes.
Pathways
Spinophilin interacts with systems involved in synaptic signaling and cytoskeletal organization. It impacts the RhoA/ROCK pathway which is essential for actin filament dynamics by modulating PP1 activity. Additionally Spinophilin indirectly affects the mTOR pathway which is involved in protein synthesis and cell growth. It relates to proteins such as RhoA and mTOR through its role in maintaining the balance of phosphorylation states within the cell.
Spinophilin's association with synaptic signaling links it to neurodegenerative diseases such as Alzheimer's disease where synaptic dysfunction is a characteristic feature. Furthermore Spinophilin's involvement in spine morphology suggests a role in psychiatric disorders like schizophrenia where altered spine density and structure are observed. In these diseases Spinophilin connects with proteins like tau in Alzheimer's and dopamine receptors in schizophrenia highlighting its potential as a therapeutic target.