Abcam, ab309356, Anti-SLC20A1 antibody [EPR27557-86]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal SLC20A1 antibody. Suitable for WB, IP and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27557-86,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLC20A1 also known as PiT-1 is a type III sodium-dependent phosphate transporter with a molecular mass of approximately 75 kDa. It helps in the uptake of inorganic phosphate into cells using sodium as a co-transport mechanism. This transport is essential for maintaining phosphate homeostasis within the body. SLC20A1 is expressed in various tissues including the liver kidney lung and cardiac tissues indicating its broad role in bodily functions.
Biological function summary
The expression of SLC20A1 plays a role in phosphate metabolism contributing to bone mineralization and cellular energy transfer. It exists as part of a complex that regulates phosphate uptake alongside its relative SLC20A2. The protein is key to cellular proliferation and survival and it influences processes like cell signaling and metabolism through its transport activity.
Pathways
Phosphate modulation by SLC20A1 interacts with cellular pathways involving calcium signaling and energy production. It is also associated with the mTOR pathway which controls cell growth and proliferation. Alongside proteins like PiT-2 SLC20A1 regulates phosphate balance which is essential for proper cellular function linking it to broader metabolic pathways.
Mutations or dysregulation of the SLC20A1 gene connect to conditions such as familial idiopathic basal ganglia calcification and hyperphosphatemia. These conditions often involve abnormal phosphate deposition in body tissues. Abnormal interactions with proteins like SCL20A2 might lead to defective phosphate uptake resulting in disease manifestations affecting neurological and renal functions.