Abcam, ab310726, Alexa Fluor® 594 Anti-Bok antibody [BOK-R1-5-1]

Size: 100µL
Rabbit Recombinant Monoclonal BOK antibody - conjugated to Alexa Fluor® 594.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:BOK-R1-5-1,
Isotype:IgG,
Conjugation:Alexa Fluor® 594,
Excitation/Emission:Ex: 590nm, Em: 617nm,
Carrier free:No,
Applications:Antibody Labelling, Target Binding AffinitySee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
BCL2-related ovarian killer (Bok) is a pro-apoptotic member of the Bcl-2 protein family contributing to apoptosis regulation. Bok sometimes referred to by its weight as approximately 23-25 kDa facilitates programmed cell death through mitochondrial pathways. Researchers have identified its expression primarily in reproductive tissues like ovaries and testis with some presence in the liver. Bok interacts with other Bcl-2 family proteins which act as apoptosis regulators creating a balance between cell survival and death.
Biological function summary
Bok plays an important role in the intrinsic apoptosis pathway by modulating mitochondrial outer membrane permeabilization. Bok forms protein complexes with other Bcl-2 family members like Bax and Bak contributing to cytochrome c release. This release is important for the activation of caspases leading to cellular apoptosis. Bok also exercises a regulatory role on calcium homeostasis within cells although its exact mechanisms remain under study.
Pathways
Bok integrates into the mitochondrial apoptosis pathway and the endoplasmic reticulum stress response influencing cellular fate decisions. Within these pathways Bok interacts with proteins such as Bax Bak and Bcl-2 balancing pro-apoptotic and anti-apoptotic signals. Bok's ability to influence these pathways demonstrates its importance in maintaining cellular homeostasis and response to stress signals.
Bok has been associated with cancer and neurodegenerative diseases. Its role in promoting apoptosis links it to conditions where apoptosis is dysregulated such as tumorigenesis where reduced Bok activity could contribute to cancer progression. In neurodegenerative disorders like Alzheimer's Bok's interaction with proteins like Bax may exacerbate neuronal loss through increased apoptosis emphasizing the need for understanding Bok in developing therapeutic strategies.