Abcam, ab313469, Anti-Laminin antibody [RP23040175]

Size: 100µg
Rabbit Recombinant Multiclonal Laminin gamma 3 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human LAMC3.
Key facts
Host species:Rabbit,
Clonality:Multiclonal,
Clone number:RP23040175,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LAMC3.Q9Y6N6

Product details:
What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:
- The sensitivity of polyclonal antibodies by recognising multiple epitopes
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
View our range of
recombinant multiclonal antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Laminin is an important protein in the extracellular matrix serving as a structural scaffold in tissues. It has several alternate names including laminine UK and laminin-1. Composed of three polypeptide chains laminin has a large molecular mass of around 850 kDa. One prominently finds laminin in the basement membranes of various tissues where it plays a critical role in maintaining tissue architecture and providing a foundation for cell attachment and growth. It interacts with cell surface receptors including integrins which help mediate cellular responses to the surrounding environment.
Biological function summary
Laminin functions by influencing cellular behaviors such as adhesion migration differentiation and proliferation. It is a pivotal component of basement membrane complexes and interacts directly with other extracellular matrix proteins like fibronectin and collagen. This interaction helps to organize the matrix and supports the structural integrity and functionality of tissues. Laminin's biological activity profoundly impacts processes such as embryonic development and wound healing where it guides cells to necessary locations and cues them to assume specific roles.
Pathways
Laminin is integral to the regulation of cell signaling pathways such as the PI3K/Akt and MAPK/ERK pathways. These pathways are critical for controlling cellular survival growth and differentiation. Laminin's interactions with integrin receptors facilitate signal transduction through these pathways promoting cellular outcomes appropriate for tissue repair and regeneration. Additionally laminin serves functions alongside other proteins like collagen in stabilizing the extracellular matrix contributing to the maintenance of tissue homeostasis and repair.
Laminin is linked to conditions like muscular dystrophy and certain types of cancer. Mutations or abnormalities in the laminin protein can disrupt muscle fiber integrity leading to degenerative disorders such as congenital muscular dystrophies. Similarly changes in laminin expression can facilitate cancer metastasis by altering cell adhesion and migration properties. In these contexts laminin's interactions with integrin and its influence on cell movement and survival become central to the disease's progression.