Abcam, ab313486, Anti-Neurogenin 2/NGN2 antibody [RP23040214]

Size: 100µg
Rabbit Recombinant Monoclonal Neurogenin 2/NGN2 antibody. Suitable for ICC/IF, WB and reacts with Human, Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Human NEUROG2.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:RP23040214,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NEUROG2.Q9H2A3

Product details:
What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:
- The sensitivity of polyclonal antibodies by recognising multiple epitopes
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
View our range of
recombinant multiclonal antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neurogenin 2 also known as NGN2 is a basic helix-loop-helix (bHLH) transcription factor. This protein weighs about 28 kDa and is found mostly in the developing central nervous system. It plays a role in the specification of neuronal lineages. Neurogenin controls the differentiation of neural progenitor cells into neurons by activating neuron-specific genes. NGN2 expression is marked in the embryonic cortex spinal cord and dorsal root ganglia.
Biological function summary
Neurogenin 2 functions as a master regulator for neuronal differentiation. It facilitates the conversion of neuroepithelial cells into neurons and is part of a transcriptional complex that includes related proteins like NeuroD. As it promotes neuron fate NGN2 partners with transcription machinery to activate neuronal gene expression. This activity shapes brain regions by directing diverse neuronal identities especially in areas critical for sensory processing.
Pathways
Several key signaling cascades involve Neurogenin 2 in neuronal development. The Notch signaling pathway is important with NGN2 directly antagonizing the effects of Hes1 a Notch target. Additionally the Wnt signaling pathway is important where NGN2 interacts with β-catenin to further regulate neural differentiation. These pathways ensure the precise coordination of neuron formation influenced by NGN2's activity alongside other essential proteins like ASCL1.
Aberrant expression or function of Neurogenin 2 associates with certain neurological conditions. One notable disorder is autism spectrum disorder (ASD) where proper neuronal circuitry under construction fails. NGN2's misregulation is also linked to neurodegenerative diseases such as Alzheimer's disease where neurons fail to maintain their identity and function. In these contexts NGN2's interaction with other transcription factors like Rest contributes to disease pathology highlighting its significant role in brain health.