Abcam, ab313494, Anti-PKA beta (catalytic subunit) + cAMP Protein Kinase Catalytic subunit [RP23040235]

Size: 100µg
Rabbit Recombinant Monoclonal cAMP Protein Kinase Catalytic subunit antibody. Suitable for ICC/IF, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PRKACA.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PRKACA.P17612

Product details:
What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:
- The sensitivity of polyclonal antibodies by recognising multiple epitopes
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
View our range of
recombinant multiclonal antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: 99.91% PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein known as PKA beta (catalytic subunit) or cAMP-dependent protein kinase catalytic subunit beta plays an important role in cellular processes. Also referred to as PKA protein kinase or PKA cAMP kinase this subunit assembles part of the PKA holoenzyme. It has a molecular mass of approximately 38 kDa. You can find its expression in various tissues including brain heart and muscle reflecting its broad functional significance.
Biological function summary
The PKA beta (catalytic subunit) mediates several cellular responses through phosphorylation. It is responsible for transferring phosphate groups to target proteins impacting diverse functions such as metabolism transcription and cell cycle. As part of the PKA subunits complex it works with regulatory subunits and cyclic adenosine monophosphate (cAMP) to modulate cellular activity by responding to changes in cAMP levels. This offers a precise control mechanism for many cellular processes.
Pathways
Mechanisms involving PKA beta (catalytic subunit) include vital roles in the PKA protein kinase signaling pathway. PKA cAMP plays a central role in the regulation of glycogen sugar and lipid metabolism. Within the signaling framework other proteins like CREB and AKAPs interact closely with the PKA cAMP pathways forming a network of regulation that ensures proper cellular function.
PKA beta (catalytic subunit) has critical associations with certain conditions. Aberrations in its expression or activity can relate to diseases such as cardiac hypertrophy and certain types of cancer. For example improper regulation of the PKA cAMP pathway affects the signaling balance contributing to cardiac structural changes. In cancer alterations in connection with proteins like PRKAR1A may influence tumor growth and progression highlighting this subunit's importance in targeted research and therapeutic strategies.