Abcam, ab314067, Anti-ThPOK antibody [BLR191J] - BSA free

Size: 100µL
Rabbit Recombinant Monoclonal ThPok antibody. Suitable for Flow Cyt, ICC, IHC-P, IP, WB and reacts with Human, Mouse samples. Immunogen corresponding to Synthetic Peptide within Human ZBTB7B aa 250-300.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:BLR191J,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:Flow Cyt, IHC-P, WB, ICC, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZBTB7B aa 250-300. The exact immunogen used to generate this antibody is proprietary information.O15156

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.8 - 8.6Preservative: 0.09% Sodium azideConstituents: 98% Borate buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ThPok also known as Th-inducing POZ-Kruppel factor or cKrox is a zinc finger transcription factor with a molecular mass of approximately 64 kDa. You find ThPok prominently expressed in CD4+ T cells where it plays a critical role in T cell development. Its primary function is to dictate CD4 versus CD8 lineage choice during T cell maturation in the thymus. ThPok is encoded by the Zbtb7b gene and this transcription factor binds to specific DNA sequences to regulate the transcription of genes vital to the immune response.
Biological function summary
The transcription factor ThPok is essential for the differentiation of naïve T cells into helper T cells. It ensures T cells develop into a type more suited to responding to pathogens. ThPok interacts with several other transcription factors and components of the T cell receptor signaling pathway. It is not part of a larger complex but works in coordination with other proteins to mediate its effects. In the absence of ThPok naïve T cells might undergo alternative development pathways.
Pathways
Signaling events critical to T cell maturation involve ThPok. For example it is an important component of the Notch signaling pathway and contributes to T cell receptor signaling which influences T cell fate decisions. Proteins such as GATA3 and Runx3 interface with ThPok within these pathways. ThPok works to suppress Runx3 expression thereby preventing CD8+ T cell lineage development when CD4+ lineage is required.
ThPok plays an important role in immune conditions like autoimmunity and immune deficiency syndromes. Irregular expression or mutations within the ThPok gene might contribute to the development of autoimmune disorders where T cells attack the body's own tissues. ThPok's interaction with proteins like Foxp3 is relevant in maintaining a balance in immune tolerance. Additionally ThPok's role in T cell differentiation links it to immune deficiency disorders that arise from impaired T helper cell function.