Abcam, ab314081, Anti-Galectin-9/Gal-9 antibody [BLR193J] - BSA free

Size: 100µL
Rabbit Recombinant Monoclonal galectin 9/Gal-9 antibody. Suitable for ICC, Flow Cyt, IHC-P, WB and reacts with Human, Mouse samples. Immunogen corresponding to Synthetic Peptide within Human LGALS9 aa 300 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:BLR193J,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:IHC-P, WB, Flow Cyt, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human LGALS9 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O00182

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.8 - 8.6Preservative: 0.09% Sodium azideConstituents: 98% Borate buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Galectin 9 also known as LGALS9 is a lectin with an approximate molecular mass of 39 kDa. This protein binds carbohydrates and plays key roles in cell signaling cell-cell interactions and immune responses. You can find Galectin 9 expressed in various tissues including lymphoid tissues the gastrointestinal tract and the liver. It interacts with glycoproteins on the cell surface contributing to diverse cellular processes.
Biological function summary
This protein modulates immune responses and induces apoptosis in certain cell types. Galectin 9 is not typically part of a stable complex but it interacts directly with other molecules influencing immunological activities. It supports interactions between various immune cells playing a part in the regulation of T-cell function and inflammatory responses thereby determining immune outcomes in the body.
Pathways
The protein interacts with T-cell immunoglobulin mucin 3 (TIM-3) in immune regulation pathways such as the autoimmune regulation pathway and the Th1/Th2 differentiation pathway. Through these interactions Galectin 9 affects cytokine production and the function of immune cells. This protein relates to important signaling events helping to modulate immune responses and maintain balance within immune systems.
Research links Galectin 9 with cancer and autoimmune disorders. In cancer Galectin 9 influences tumor immunity partly through its interaction with TIM-3 affecting tumor elimination or growth. In autoimmune diseases like rheumatoid arthritis Galectin 9 impacts inflammatory responses possibly contributing to disease progression by modulating the activity of immune cells involved in autoimmunity.