Abcam, ab314168, Anti-Dynamin 2 antibody [1D8]

Size: 100µL
Rabbit Monoclonal Dynamin 2 antibody. Suitable for WB, ICC/IF, Flow Cyt and reacts with Human, Rat samples. Immunogen corresponding to Synthetic Peptide within Human DNM2.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:1D8,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Rat,
Applications:WB, Flow Cyt, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DNM2.P50570

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Dynamin 2 also known as dynamin protein or DNM2 is a GTPase enzyme with a mass of approximately 100 kDa. This protein is mainly found in human cells such as fibroblasts epithelial cells and neurons. It functions by facilitating membrane fission events which are important for endocytosis and other vesicular trafficking processes. The flexible structure of dynamin-2 allows it to act as a molecular motor generating mechanical force upon GTP hydrolysis to constrict and sever membranes.
Biological function summary
Dynamin 2 participates in cellular processes like receptor-mediated endocytosis and are involved in actin and microtubule dynamics. It associates with other proteins to form complexes that stabilize its function and activity within the cell. By enabling endocytosis dynamin-2 plays a role in nutrient uptake signaling and membrane recycling ensuring proper cellular function and homeostasis.
Pathways
Dynamin 2 is integral to the clathrin-mediated endocytic pathway and the actin cytoskeleton regulation pathway. In the clathrin-mediated pathway it interacts with clathrin and adaptin proteins to facilitate the budding and release of clathrin-coated vesicles. Within the actin cytoskeleton pathway dynamin-2 is related to actin-binding proteins which it assists in remodeling the cytoskeleton structure supporting cell shape and motility.
Mutations in dynamin 2 have been linked to Charcot-Marie-Tooth disease and centronuclear myopathy. These conditions affect peripheral nerves and skeletal muscles respectively and stem from dysfunction in the cellular trafficking and division processes mediated by dynamin-2. The pathology of these diseases involves connections with other proteins such as myotubularin and other muscular-associated proteins indicating the significance of dynamin-2 in maintaining normal cellular functions and its role in neuromuscular disorders.