Abcam, ab314286, PE Anti-GPCR LGR6 antibody [EPR6874]

Size: 100µL
Rabbit Recombinant Monoclonal GPCR LGR6 antibody - conjugated to PE. Suitable for Flow Cyt (Intra) and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6874,
Isotype:IgG,
Conjugation:PE,
Excitation/Emission:Ex: 480;565nm, Em: 578nm,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPCR LGR6 also known as leucine-rich repeat-containing G protein-coupled receptor 6 is a transmembrane receptor that belongs to the large GPCR family. It has a molecular weight of approximately 98 kDa. LGR6 expresses in various tissues including skin bone and certain regions of the brain. The receptor binds specific ligands which initiates signal transduction pathways that mediate various cellular responses. This function places LGR6 as an important component in multiple physiological processes.
Biological function summary
LGR6 plays an important role in signaling pathways involved in stem cell maintenance and tissue regeneration. It functions together with other proteins as part of a larger receptor complex. In the skin LGR6 marks a population of stem cells involved in hair follicle cycling and epidermal renewal. Its activity influences the cellular communication required for tissue homeostasis and repair. This receptor helps in determining cellular fate and proliferation in various tissues.
Pathways
LGR6 participates in the Wnt signaling pathway which is important for cell differentiation growth and migration. LGR6 interacts with proteins such as R-spondins enhancing Wnt signaling. This connection highlights LGR6's role in modulating pathways essential for embryonic development and tissue patterning. The interaction with Wnt and related proteins positions LGR6 as a modulator of pathways that govern stem cell behavior.
Abnormalities in LGR6 function have associations with skin disorders and cancers. Mutations or dysregulation of LGR6 can lead to impaired wound healing and contribute to pathological conditions. In cancer LGR6 has connections with proteins that affect tumor growth and metastasis. Studies suggest involvement of LGR6 in pathways related to squamous cell carcinoma further linking it with proteins involved in cancer progression therefore underlining its potential as a therapeutic target.