Abcam, ab314354, Human SREC-II ELISA Kit

Size: 1 x 96Tests
Human SREC-II ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human SREC-II in Human in Cell Culture Media, Biofluids samples.
Key facts
Detection method:Colorimetric,
Sample types:Cell culture supernatant, Plasma, Serum,
Reacts with:Human,
Assay type:Sandwich (quantitative),
Sensitivity:= 0.84 ng/mL,
Range:0.84 - 200 ng/mL,
Assay Platform:Pre-coated microplate (12 x 8 well strips)

Product details:
Human SREC-II ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human SREC-II in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human SREC-II coated on a 96-well plate.
This ELISA kit shows no cross-reactivity with the following cytokines tested: human ACE, Activin RIB (ALK-4), ADAM23, Artemin, Cardiotrophin1 (CT-1), Cathepsin V, FABP1 (L-FABP), FGF-20, GDF-8 (Myostatin), HAI-1, IL-27 R alpha (WSX-1), Insulin R (CD220), Kallikrein 7, LIF R alpha, Lipocalin-1, LTbR (Lymphotoxin beta R), Mesothelin, MFRP, Neuropilin-2, Neurturin, Nidogen-2, Olfactomedin-2 (Noelin-2), p53, PDECGF (Thymidine Phosphorylase), PDGF-CC, Progranulin, Ret, ROBO4, Semaphorin 6B, Serpin F1 (PEDF), SREC-I (SCARF1), TLR1, TLR3, TPP1 (Tripeptidyl-peptidase I), TREM-2, TrkC, TROY (TNFRSF19), Uromodulin, XIAP.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SCARF2 protein also known as SREC-II (scavenger receptor class F member 2) is a cell surface glycoprotein involved in endocytosis and signaling. It has an approximate molecular weight of 92 kDa. This protein mainly expresses in tissues such as the placenta lung and liver and is also found in the skin and heart. SCARF2 binds to lipoproteins apoptotic cells and pathogens displaying a range of interactions essential for its function.
Biological function summary
Within the cellular context SCARF2 influences processes like lipid metabolism and immune response. While it functions mostly independently SCARF2 occasionally interacts with other scavenger receptors for efficient uptake of modified low-density lipoproteins. Its binding abilities connect it to cellular housekeeping and pathogen clearance roles contributing to maintenance of cellular homeostasis and defense mechanisms.
Pathways
Interactions involving SCARF2 influence lipid metabolism and immune signaling networks. It plays a role in lipid transport pathways where it potentially associates with proteins like CD36 which also bind lipoproteins. In immune pathways SCARF2 affects toll-like receptor signaling interacting indirectly with proteins such as TLR4 contributing to the modulation of inflammatory responses.
Researchers have identified connections between SCARF2 and atherosclerosis as well as skin disorders like ichthyosis. In atherosclerosis SCARF2 mediates lipoprotein uptake possibly influencing the pathogenesis alongside proteins like LOX-1. In ichthyosis mutations in SCARF2 have been observed linking it to abnormal cornification processes with impacts that potentially involve interactions with proteins like transglutaminase.