Abcam, ab314386, Human SCARA5 ELISA Kit

Size: 1 x 96Tests
Human SCARA5 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human SCARA5 in Human in Biofluids, Cell Culture Media samples.
Key facts
Detection method:Colorimetric,
Sample types:Serum, Plasma, Cell culture supernatant,
Reacts with:Human,
Assay type:Sandwich (quantitative),
Sensitivity:= 0.05 ng/mL,
Range:0.05 - 10 ng/mL,
Assay Platform:Pre-coated microplate (12 x 8 well strips)

Product details:
Human SCARA5 ELISA Kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human SCARA5 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human SCARA5 coated on a 96-well plate.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCARA5 also known as scavenger receptor class A member 5 functions mechanically as a cell surface receptor involved in the endocytosis of iron-bound lipocalin-2. This protein has a mass of approximately 86 kDa. SCARA5 is expressed in various tissues including the placenta lung liver and prostate. It plays a role in binding and internalizing ligands leading to their transport into the cells where they are involved in further biological processes.
Biological function summary
SCARA5 plays a role in iron homeostasis as it modulates the cellular uptake of lipocalin-2 and its associated ferric-siderophore complexes. SCARA5 does not work alone; it operates as part of a complex involving ligands such as lipocalin-2 which can influence iron levels in cells and tissues. This interaction is necessary for maintaining proper iron balance and supporting cellular functions that rely on iron availability.
Pathways
SCARA5 is involved in the iron metabolism pathway and influences cellular iron uptake. This pathway interacts with other proteins like hepcidin and ferroportin which are essential for maintaining systemic iron balance. These interactions help to regulate iron absorption transport and storage within the body ensuring adequate iron is available for critical processes like red blood cell production and oxygen transport.
SCARA5 is associated with disorders like iron overload conditions and certain types of cancer. Abnormal SCARA5 expression or function may lead to disrupted iron homeostasis which can contribute to iron overload in tissues. Additionally SCARA5 expression has been linked to cancers such as hepatocellular carcinoma where it may interact with proteins like transferrin receptor to impact tumor growth and progression. Understanding its role in these conditions may provide insights into therapeutic targets and treatment strategies.