Abcam, ab314431, Anti-KLF2 antibody [EPR23420-40] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal KLF2 antibody. Carrier free. Suitable for WB and reacts with Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR23420-40,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KLF2 also known as Kruppel-like factor 2 is a transcription factor with a molecular mass of approximately 37 kDa. It belongs to the Kruppel-like family of transcription factors which share zinc finger domains. KLF2 regulates gene expression by binding to specific DNA sequences in promoters influencing cellular processes. Researchers have localized its expression predominantly in the vascular endothelium the lungs and the spleen. In these tissues KLF2 influences endothelial cell function and vascular biology.
Biological function summary
KLF2 mediates cellular processes including endothelial cell maintenance and vascular development. As a transcription factor KLF2 does not operate as part of a multi-protein complex but rather performs its regulatory function individually by modulating target gene expression. KLF2 activates genes associated with anti-inflammatory and anti-thrombotic properties in endothelial cells contributing to vascular homeostasis. Its role is key in maintaining the balance between pro- and anti-inflammatory signals in the vascular system.
Pathways
KLF2 integrates its function into various signaling pathways notably the MEK/ERK and PI3K/Akt pathways. KLF2 modulates these pathways to control proliferation differentiation and apoptosis in endothelial cells. In particular KLF2-induced gene expression influences these pathways by interacting with other proteins such as MEK and ERK proteins that regulate cell survival and inflammatory responses. These interactions highlight the relevance of KLF2 in cellular signaling important for vascular health.
KLF2 has significant implications for cardiovascular diseases and atherosclerosis. Research associates KLF2 with protective roles against the development of atherosclerosis due to its influence on endothelial function and inflammation. When KLF2 expression is compromised the risk for thrombosis and vascular inflammation increases contributing to cardiovascular conditions. Additionally studies link KLF2 to the pathophysiology of diabetes where aberrant KLF2 expression disrupts normal endothelial functions exacerbating diabetic complications. KLF2 interacts with proteins like NF-kB in such conditions impacting the expression of genes involved in inflammation and metabolism.