Abcam, ab315031, Anti-PCDHAC2 antibody [EPR28522-31]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal PCDHAC2 antibody. Suitable for WB, I-ELISA, IP and reacts with Human, Mouse, Rat, Recombinant fragment - Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28522-31,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, IP, I-ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Unsuitable for human IP.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PCDHAC2 also known as protocadherin alpha C2 is part of the protocadherin alpha subfamily. This protein has a molecular mass of approximately 105 kDa. It localizes to the cell membrane prominently expressed in neural tissues. PCDHAC2 functions in cell-cell adhesion mediated largely through calcium-binding motifs in its extracellular domain. These interactions contribute to cellular communication and signal transduction essential for the nervous system development.
Biological function summary
Protocadherins like PCDHAC2 play pivotal roles in the neural architecture by mediating homophilic cell adhesion properties. PCDHAC2 does not function as a solitary entity; it forms part of multimeric cadherin complexes at cell junctions. Its ability to mediate specific cell-cell interactions enhances neural circuit organization and synaptic specificity. The precise patterning of these interactions contributes to the establishment of proper brain architecture and connectivity.
Pathways
PCDHAC2 integration involves the calcium-dependent cell adhesion pathway and the Wnt signaling pathway. These pathways are critical for embryonic development and neural differentiation. In these pathways the protein interacts with other cadherins and catenins providing stability and signaling functions. Its actions might regulate cytoskeletal dynamics influencing the neural network's architecture indirectly by modulating the expression of cytoplasmic proteins linked to cellular adhesion and signaling.
Aberrant PCDHAC2 expression or function connects to neurological disorders such as autism spectrum disorder and schizophrenia. These conditions may involve disruptions in neural connectivity and synaptic function. PCDHAC2-related dysfunctions can affect interactions with proteins like beta-catenin which are significant in signal transduction and synaptic structure. Understanding these associations may provide insights into the molecular pathology underpinning these disorders.