Abcam, ab315093, Anti-Pan Cav2 antibody [EPR28073-84] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal CACNA1A antibody. Carrier free. Suitable for WB, IHC-P, IHC-Fr and reacts with Mouse, Rat, Transfected cell lysate - Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28073-84,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat,
Applications:IHC-Fr, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab315093 is the carrier-free version of
ab315092
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pan Cav2 also known as Cav2 channels or voltage-gated calcium channels of the Cav2 family function mechanically to facilitate the influx of calcium ions through cellular membranes in response to membrane depolarization. These channels are important for converting electrical signals into calcium signals which play a big role in various cellular processes. Cav2 channels typically compose of the α1 subunit and several auxiliary subunits. The α1 subunit has an approximate mass of 190-250 kDa. Cav2 channels express widely throughout the nervous system including in neurons of the brain and spinal cord and also in cardiac and skeletal muscle cells.
Biological function summary
Cav2 channels play key roles in neurotransmitter release muscle contraction and hormone secretion. These channels form part of multiprotein complexes that involve various auxiliary subunits which modulate their function and localization. Through their regulation of calcium influx Cav2 channels critically impact synaptic transmission and plasticity in neuronal communication. They also contribute to excitation-contraction coupling in muscle cells enabling the precise control of muscle actions.
Pathways
Cav2 channels heavily influence calcium signaling pathways and synaptic plasticity pathways. Within the calcium signaling pathway their activity directly alters intracellular calcium concentrations which modulate downstream signaling cascades. These channels closely interact with proteins such as SNARE proteins and synaptotagmin in neurotransmitter release. In pathways related to synaptic plasticity Cav2 channels influence long-term potentiation impacting learning and memory processes.
Cav2 channel dysfunction associates with neurological disorders such as migraine and epilepsy. Aberrant expression or mutation of Cav2 channel components disrupts normal neural excitation leading to these disorders. The channels also connect with auxiliary proteins such as α2δ subunits that can alter pain pathways implicating them in certain pain disorders. Moreover irregularities in Cav2 channel function may link to cardiac arrhythmias through interactions with cardiac proteins responsible for proper heartbeat rhythm.