Abcam, ab315476, Anti-Perilipin 3/TIP47 antibody [EPR28801-93]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Perilipin 3/TIP47 antibody. Suitable for Flow Cyt (Intra), WB, ICC/IF, IP and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28801-93,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, Flow Cyt (Intra), IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Perilipin 3 also known as TIP47 is a lipid droplet-associated protein with a molecular weight of approximately 47 kDa. This protein expresses in a variety of tissues especially those involved in lipid metabolism like adipose tissue and liver. Perilipin 3 localizes on the surface of lipid droplets where it plays an important role in managing lipid storage and mobilization. This protein interacts directly with the lipid droplet surface facilitating stabilization and regulation of lipid content.
Biological function summary
Perilipin 3 acts as a mediator in lipid droplet dynamics and is part of the perilipin family of proteins. These proteins are key modulators of lipid storage and release ensuring balance within lipid metabolism. Perilipin 3 does not form a complex but has functional interactions with other perilipin proteins like perilipin 1 and perilipin 2 which synergize in the regulation of lipid droplets. This interaction ensures the efficiency of lipid metabolism processes and energy homeostasis in cells.
Pathways
Perilipin 3 participates in lipid metabolism and energy homeostasis pathways. It works alongside proteins such as adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) to manage the lipolytic process. This involves the breakdown of stored triglycerides into free fatty acids and glycerol. The protein is integral in the regulation of lipid storage and catabolism pathways facilitating energy release during increased energy demand conditions.
Perilipin 3 has connections to metabolic diseases such as obesity and lipid storage disorders. Aberrant function or expression of perilipin 3 can lead to disrupted lipid metabolism and contribute to these conditions. Research shows that perilipin 3 works with proteins like ATGL in these contexts as alterations in their activities affect lipid handling. Understanding the role of perilipin 3 in these disorders can lead to better therapeutic strategies targeting metabolic dysfunctions.