Abcam, ab315831, Anti-AAV5 antibody [HL2476]

Size: 10µg-TRIAL / 20µg / 50µg
Mouse Recombinant Monoclonal AAV5 antibody. Suitable for I-ELISA, Dot and reacts with Recombinant fragment - adeno-associated virus 5 samples.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:HL2476,
Isotype:IgG2b,
Carrier free:No,
Reacts with:adeno-associated virus 5,
Applications:Dot, I-ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The biological target AAV5 or Adeno-Associated Virus type 5 is a non-pathogenic virus used widely as a vector in gene therapy. This virus has a protein structure named the AAV5 capsid which serves as its protective shell. The AAV5 capsid has an estimated mass of 60 megadaltons and plays an important role in virus stability and infectivity. AAV5 is expressed in various tissues but its expression pattern can differ based on the type of tissue and species being studied.
Biological function summary
The AAV5 capsid facilitates entry into host cells by interacting with cellular receptors. It is not a component of a larger complex but its role is important for delivering genetic material into cells. The virus's ability to transduce a wide range of cell types makes it highly effective in gene therapy applications. This versatility allows researchers to target specific tissues and diseases.
Pathways
AAV5 plays an important role in gene delivery systems which can impact the expression of genetically targeted therapies. Its interaction with heparan sulfate proteoglycans during cellular entry highlights its involvement in pathways related to cellular uptake and transfer of genetic material. This function is highly relevant when considering AAV5 as a tool for introducing therapeutic genes into cells alongside proteins like other adeno-associated viruses which may share similar pathways.
AAV5 has emerged as a powerful tool in the treatment of genetic disorders such as hemophilia and neurodegenerative diseases. Its ability to transduce non-dividing cells makes it suitable for long-term expression in cells. AAV5's interaction with the coagulation factor IX protein can provide therapeutic benefits in hemophilia B patients when delivered effectively. It also shows promise in delivering genes to neural tissues potentially aiding in treating disorders like Parkinson’s disease.